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    當前位置:首頁 > 新聞中心 > Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體

    Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體

    更新時間:2011-10-05      點擊次數:5168

    Imgenex公司表觀遺傳學研究工具:Dnmt與HDAC抗體
     
    Dnmt and HDAC Antibodies for Epigenetics
    Cell Regulation & DNA Repair
     
    Histonedeacetylases exert transciptional control through deacetylation of core histone proteins. DNA methyltransferases regulate gene expression through cytosine methylation –changes in methylation patterns have been linked with neoplasia development. As a recognized leader and tool provider for cell regulatory pathway analysis, IMGENEX provides a comprehensive choice of highly referenced, validated antibodies specific for HDACs and Dnmts. We are continuing to build upon our leading portfolio for studying cell regulation by introduction of new products including transcription factors, ChIP Kits, signaling molecules and other key biomarkers. Utilization of our Pathway Profiling expertise and products continues to enable advanced research in Cancer, Apoptosis, Stem Cell/Developmental Biology and Immune/Inflammation Signaling Pathways.
     
    Applications:
    •  Western Blot
    •  IHC
    •  ChIP
    •  Flow Cytometry
     
     
    HDAC Antibodies
    HDAC-1 HDAC-6
    HDAC-2 (Ab-394) HDAC-7
    HDAC-3 HDAC-7 (Ser155)
    HDAC-4 HDAC-7 (Ser318)
    HDAC-4 (Ab-632) HDAC-7 (Ser448)
    HDAC-4 (Ser632) HDAC-8 (Ab-39)
    HDAC-5 HDAC-8 (Ser39)
    HDAC-5 (Ab-498) HDAC-9
    HDAC-5 (Ser498)  
     
    Dnmt Antibodies
    Dnmt1 Dnmt3a
    Dnmt2 Dnmt3b
     
    Related Pathways
    Transcription Factors
    Apoptosis Detection Kits/pSIVA
    NF-kB Pathway
     
    Dnmt3a, IMG-268A
    Expression of Dnmt3a in the nuclei of post-mitotic neurons in the olfactory epithelium (OE). DNMT3a (red) is co-expressed with neuron-specific tubulin (green) throughout the development of the olfactory epithelium, using IMG-268A. (Data courtesy of A. Jane Roskams, University of British Columbia).
     
    HDAC-7 (Ser155), IMG-612
    Western blot analysis of phosphorylated HDAC-7 in (A) recombinant fusion protein containin a phosphorylated serine at position 155 and (B) fusion protein containing an unphosphorylated serine at position 155, using IMG-612 at 0.1 ug/ml.

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